Messenger RNA (mRNA) is the intermediate that nature uses to translate genetic information into proteins. Its natural form determines its half-life and expression level.
Endogenous mRNA – from DNA to protein
ACCANIS is developing optimized, proprietary in vitro transcribed (IVT) mRNA with broad and long-acting therapeutic potential surpassing protein-based therapeutics.
In vitro transcribed (IVT) mRNA – from transcript to therapy
In vitro transcribed (IVT) mRNA:
- Structurally resembles cellular mRNA
- Recognized by the cell to produce proteins
- Naturally degraded by the cell
IVT mRNA allows for:
- External control of gene expression
- Programmable half-life/stability
Formulation can be adapted to need:
- Naked mRNA vs. mRNA formulated with transfection/delivery reagents
