Messenger RNA (mRNA) is the intermediate that nature uses to translate genetic information into proteins. Its natural form determines its half-life and expression level.

Endogenous mRNA – from DNA to protein


ACCANIS is developing optimized, proprietary in vitro transcribed (IVT) mRNA with broad and long-acting therapeutic potential surpassing protein-based therapeutics.

In vitro transcribed (IVT) mRNA – from transcript to therapy


In vitro transcribed (IVT) mRNA:

  • Structurally resembles cellular mRNA
  • Recognized by the cell to produce proteins
  • Naturally degraded by the cell

IVT mRNA allows for:

  • External control of gene expression
  • Programmable half-life/stability

Formulation can be adapted to need:

  • Naked mRNA vs. mRNA formulated with transfection/delivery reagents

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